The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling.

P-17: Modulation of Wnt/?catenin and AktSignaling Activities in Rat Granulosa Cells byUsing Recombinant Secreted Frizzled RelatedProtein Type-4

A colipase fold in the carboxy-terminal domain of the Wnt antagonists – the Dickkopfs

It has recently been shown that a class of secreted proteins — the Dickkopfs — are released by the Spemann organizer of Xenopus and are potent antagonists of Wnt signaling [1]. Although it has been reported that the Dickkopf (Dkk) proteins contain two cysteine-rich domains, no direct functional or structural conclusions have been drawn from their sequences. The role of Wnt signaling in animal d...

The agony column

It has recently been shown that a class of secreted proteins — the Dickkopfs — are released by the Spemann organizer of Xenopus and are potent antagonists of Wnt signaling [1]. Although it has been reported that the Dickkopf (Dkk) proteins contain two cysteine-rich domains, no direct functional or structural conclusions have been drawn from their sequences. The role of Wnt signaling in animal d...

Protein folding: Think globally, (inter)act locally

It has recently been shown that a class of secreted proteins — the Dickkopfs — are released by the Spemann organizer of Xenopus and are potent antagonists of Wnt signaling [1]. Although it has been reported that the Dickkopf (Dkk) proteins contain two cysteine-rich domains, no direct functional or structural conclusions have been drawn from their sequences. The role of Wnt signaling in animal d...

The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.

Wnts control a wide range of essential developmental processes, including cell fate specification, axon guidance and anteroposterior neuronal polarization. We identified a conserved transmembrane RING finger protein, PLR-1, that governs the response to Wnts by lowering cell-surface levels of the Frizzled family of Wnt receptors in Caenorhabditis elegans. Loss of PLR-1 activity in the neuron AVG...